Prossimi Eventi
Irreversible gating transitions in TRPV1 ion channels
Relatore: Leon Islas (Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México).
Abstract: Temperature activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We carefully characterize the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening and might reflect partial unfolding of one or more regions of the protein.
Data inizio evento: 28/06/2018 12:00
Luogo: Aula Seminari, S3, Dipartimento Scienze Fisiche Informatiche, Matematiche, via Campi 213/A, Modena
Categorie: eventi, Seminario, scienze
Pubblicato da: comunicazione@unimore.it